(Please contact Susan Halkiotis at for reprint requests.)


Kunicki C, Moioli RC, Pais-Vieira M, Peres ASC, Morya E, Nicolelis MAL. Frequency-specifc coupling in fronto-parieto-occipital cortical circuits underlie active tactile discrimination. Rep. 9, Article number: 5105.


Shokur S, Donati ARC, Campos DSF, Gitti C, Bao G, Fischer D, Almeida S, Braga VAS, Augusto P, Petty C, Alho EJL, Lebediev M, Song AW, Nicolelis MAL. Training with brain-machine interfaces, visuotactile feedback and assisted locomotion improves sensorimotor, visceral, and psychological signs in chronic paraplegic patients. PLoS ONE13(11): e0206464., 2018.

Yin A, Tseng PH, Rajangam S, Lebedev MA, Nicolelis MAL. Place cell-like activity in the primary sensorimotor and premotor cortex during monkey whole-body navigation. Sci. Rep. doi: 10.1038/s41598-018-27472-4, 2018.

Tseng P-H, Rajangam S, Lehew G, Lebedev MA, Nicolelis MAL. Interbrain cortical synchronization encodes multiple aspects of social interactions in monkey pairs. Sci. Rep., 2018.


Thomson E, Zea I, Windham W, Thenaisie Y, Walker C, Pedowitz P, França W, Graneiro AL, Nicolelis MAL. Merging visible and invisible light using a cortical neuroprosthesis without impairing native sensory function. eNeuro doi: 10.1523/ENEURO.0262-17, 2017.

Ramakrishnan A, Byun YW, Rand K, Pedersen C, Lebedev MA, Nicolelis MA. Cortical Neurons Multiplex Reward-Related Signals along with Sensory and Motor Information. Proc Natl Acad Sci doi: 10.1073/pnas.1703668114, 2017.

Nicolelis, MAL. Are we at risk of becoming biological digital machines? Nat. Hum. Behav. 1: Art. 8, doi: 10.1038/s41562-016-0008, 2017.

Lebedev  M and Nicolelis MAL Brain-machine interfaces: from basics science to neuroprosthetic devices, and neurorehabilitation. Physiol. Rev. 97: 767-837, 2017.

Yadav A and Nicolelis MAL. Electrical stimulation of the dorsal columns of the spinal cord in Parkinson’s disease. Mov. Disord. doi: 10.1002/mds.27033, 2017.


Donati ARC, Shokur S, Morya E, Campos DSF, Moioli RC, Gitti CM, Augusto PB, Tripodi S, Pires CG, Pereira GA, Brasil FL, Gallo S, Lin A, Takigami AK, Aratanha MA, Joshi S, Bleuler H, Cheng G, Rudolph A, Nicolelis MAL. Long-term training with brain-machine interfaces induces partial neurological recovery in paraplegic patients. Sci. Rep. doi: 10.1038/srep30383, 2016.

Pais-Vieira M, Yadav AP, Moreira D, Guggenmos D, Santos A, Lebedev MA, Nicolelis MA. A Closed Loop Brain-machine Interface for Epilepsy Control Using Dorsal Column Electrical Stimulation. Sci. Rep. doi:10.1038/srep32814, 2016.

Shokur S, Gallo S, Moioli RC, Donati ARC, Morya E, Bleuler H, Nicolelis MA. Assimilation of virtual legs and perception of floor texture by complete paraplegic patients receiving artificial tactile feedback. Sci. Rep. doi:10.1038/srep32293,2016.

Rajangam S, Tseng P-H, Yin A, Lehew G, Schwarz D, Lebedev MA, Nicolelis MA. Wireless Cortical Brain-Machine Interface for Whole-Body Navigation in Primates. Sci. Rep. doi:10.1038/srep22170, 2016.

Yin A, An J, Lehew G, Lebedev MA, Nicolelis MAL. An automatic experimental apparatus to study arm reaching in New World monkeys. J. Neurosci. Methods doi:10.1016/j.jneumeth.2016.02.017, 2016.

Thomson EE, Hartmann K, Yun R, Mullen P, Canarick J, Huh A, Nicolelis MA. Embedding a novel representation of infrared light in the adult rat somatosensory cortex through a sensory neuroprosthesis. J. Neurosci. 36:2406 –2424, 2016.


Pais-Vieira M, Kunick C, Tseng P-H, Martin J, Lebedev M, Nicolelis MAL. Cortical and thalamic contributions to response dynamics across layers of the primary somatosensory cortex during tactile discrimination. J. Neurophys. 114: 1652–1676, 2015.

Pais-Vieira M, Chiuffa G, Lebedev MA, Yadav A, Nicolelis MA. Building an organic computing device with multiple interconnected brains. Sci. Rep. doi:10.1038/srep11869, 2015.

Ramakrishnan A, Ifft PJ, Pais-Vieira M, Byun YW, Zhuang KZ, Lebedev MA, Nicolelis MAL. Computing Arm Movements with a Monkey Brainet. Sci. Rep. doi:10.1038/srep10767, 2015.


Zhuang KZ, Lebedev MA, O’Doherty JE, Nicolelis MAL. Joint cross-correlation analysis reveals complex, time-dependent functional relationship between cortical neurons and arm electromyograms. J. Neurophysiol.  112: 2865-2887, 2014.

Santana MB, Halje P, Simplicio H, Richter U, Freire M, Petersson P, Fuentes R, Nicolelis MAL. Spinal Cord Stimulation Alleviates Motor Symptoms in a Primate Model of Parkinson’s disease. Neuron, 2014.

Zacksenhouse M, Lebedev MA, Nicolelis MAL. Signal-Independent Timescale Analysis (SITA) and its Application for Neural Coding during Reaching and Walking. Front. Comput. Neurosci. doi: 10.3389/fncom.2014.00091, 2014.

Thomson EE, Lou J, Sylvester K, McDonough A, Nicolelis, MAL. Basal forebrain activity during a tactile discrimination task. J. Neurophysiol. 112: 1179–1191, 2014.

Schwarz D, Lebedev MA, Tate A, Hanson T, Lehew G, Melloy J, Dimitrov D, Nicolelis MAL. Chronic, Wireless Recordings of Large Scale Brain Activity in Freely Moving Rhesus Monkeys. Nat. Methods doi:10.1038/nmeth.2936, 2014.

Yadav AP, Fuentes R, Zhang H, Vinholo T, Wang C-H, Nicolelis MAL. Chronic Spinal Cord Stimulation Protects against 6-hydroxydopamine Lesions. Sci. Rep. 4: 3839. doi: 10.1038/srep03839, 2014.


Ifft P, Shokur S, Li Z, Lebedev MA, Nicolelis MAL. A Brain-Machine Interface Enables Bimanual Arm Movements in Monkeys. Sci. Transl. Med. 5: 210, DOI:10.1126/scitranslmed.3006159, 2013.

Thomson EE, Carra R, Nicolelis MAL. Perceiving Invisible Light through a Somatosensory Cortical Prosthesis. Nat. Commun. 10.1038/ncomms2497, 2013.

Vieira M, Lebedev MA, Nicolelis MAL. Top-down Modulation in Cortico-Thalamo-Cortical Loops during Active Tactile Discrimination. J. Neurosci. 33:4076–4093, 2013.

Vieira M, Lebedev MA, Kunicki C, Wang J, Nicolelis MAL. A brain-to-brain interface for real-time sharing of sensorimotor information. Sci. Rep. 3:1319, doi:10.1038/srep01319, 2013.

Dzirasa K, Kumar S, Sachs B, Caron MG, Nicolelis MAL. Cortical-amygdalar circuit dysfunction in a genetic mouse model of serotonin deficiency. J. Neurosci. 33: 4505-4513, 2013.

Shokur S, O’Doherty J.E., Winans J.A., Bleuler H., Lebedev M.A., Nicolelis M.A.L. Expanding the primate body schema in sensorimotor cortex by virtual touches of an avatar. Proc. Natl. Acad. Sci. 110: 15121-6, doi: 10.1073/pnas.1308459110, 2013.


Medina LE, Lebedev MA, O’Doherty JE, Nicolelis MAL. Stochastic Facilitation of Artificial Tactile Sensation in Primates.  J. Neurosci. 32: 14271-14275, 2012.

Ifft PJ, Labedev MA, Nicolelis MAL. Reprogramming movements: Extraction of motor intentions from cortical ensemble activity when movement goals change. Front. Neuroeng. 5:16, 2012.

Tandon S, Simon SA, Nicolelis MAL. Appetitive Changes Associated with Salt Deprivation are Paralleled by Widespread Neuronal Adaptations in the Nucleus Accumbens, Lateral Hypothalamus and Central Amygdala. J. Neurophysiol. 108: 1089–1105, 2012.

Nicolelis MA. Mind in Motion. Sci. Am. 307: 58-63, 2012.

Hanson T, Omarsson B, O’Doherty J, Peikon I, Lebedev M, Nicolelis M. High-side digitally current controlled biphasic bipolar microstimulator. IEEE Trans Neural Syst Rehabil Eng. 20: 331-340, 2012.

Hanson TL, Fuller AM, Lebedev MA, Turner DA, Nicolelis MAL. Subcortical Neuronal Ensembles: An Analysis of Motor Task Association, Tremor, Oscillations, and Synchrony in Human Patients. J. Neurosci. 32:8620–8632, 2012.

Oliveira-Maia AJ, de Araujo IE, Monteiro C, Workman V, Galhardo V,  Nicolelis MAL. The Insular Cortex Controls Food Preferences Independently of Taste Receptor Signaling. Front. Integr. Neurosci. 6: 5, 2012.


Nicolelis MAL. Mind out of Body. Sci. Am. 304: 80-83, 2011.

Oliveira-Maia A J, Roberts C D, Simon S A, Nicolelis M A L. Gustatory and reward brain circuits in the control of food intake. Adv. Tech. Stand. Neurosurg. 36:31-59, 2011.

Dzirasa K, Fuentes R, Potes JM, Nicolelis MAL. Chronic in vivo multi-circuit neurophysiological recordings in mice. J. Neurosc. Methods 195: 36-46, 2011.

Dzirasa K, McGrarity D, Bhattacharya A, Kumar S, Takahashi J, Dunson D, McClung C, Nicolelis M A. Impaired limbic gamma oscillatory synchrony during anxiety related behavior in a genetic mouse model of bipolar mania. J. Neurosc. 31:6449-6456, 2011.

Nicolelis, MAL. Wired-up brains will offer out of body experience. New Scientist,  Issue 2813, pp. 26-27, 2011.

Lopes-dos-Santos V, Conde-Ocazionez S, Nicolelis MA, Ribeiro ST, Tort AB. Neuronal assembly detection and cell membership specification by principal component analysis. PLoS One 6:e20996, 2011.

Lebedev MA, Tate AJ, Hanson TL, Li Z, O’Doherty JE, Winans JA, Ifft PJ, Zhuang KZ, Fitzsimmons NA, Schwarz DA, Fuller AM, An JH, Nicolelis MA. Future developments in brain-machine interface research. Clinics (Sao Paulo) 66 Suppl 1:25-32, 2011.

Lebedev, MA, Nicolelis MAL. Toward a whole body neuroprosthetic. Prog. Brain Res.  194: 47-60, 2011.

Freire MA, Morya E, Faber J, Santos JR, Guimaraes JS, Lemos NA, Sameshima K, Pereira A, Ribeiro S, Nicolelis MA. Comprehensive analysis of tissue preservation and recording quality from chronic multielectrode implants. PLoS One 6:e27554, 2011.

O’Doherty JE, Lebedev MA, Ifft PJ, Zhuang KZ, Shokur S, Bleuler H, Nicolelis MAL. Active tactile exploration enabled by a brain-machine-brain interface. Nature 479: 228-231, 2011.

Li, Z, O’Doherty, JE, Lebedev, MA, Nicolelis, MAL. Adaptive decoding for brain-machine interfaces through Bayesian parameter updates.  Neural Comput. 23: 1–43,  2011.

Oliveira-Maia AJ, Roberts C, Walker QD, Luo B, Kuhn C, Simon SA, Nicolelis MA. Intravascular Food Reward. PLoS One 6(9): e24992. doi:10.1371/journal.pone.0024992, 2011.

O’Doherty JE, Lebedev MA, Li Z, Nicolelis MAL. Towards a brain-machine interface: active touching using randomly patterned intracortical microstimulation. IEEE Trans Neur Syst Rehab Eng. 20:  85-93, 2011.

Zhang H, Lin SC, Nicolelis MA. A distinctive subpopulation of medial septal slow-firing neurons promote hippocampal activation and theta oscillations. J Neurophysiol. 106: 2749-2763, 2011.

Ifft PJ, Lebedev MA, Nicolelis MAL. Cortical Correlates of Fitts’ Law. Front. Integr. Neurosci. 5: 85, 2011.


Gutierrez R, Simon SA, Nicolelis MAL. Licking induced neural synchronization improves taste discrimination during learning. J. Neurosci. 30:287–303, 2010.

Thiagarajan TC, Lebedev MA, Nicolelis MA, Plenz D. Coherence Potentials: Loss-Less, All-or-None Network Events in the Cortex. PLoS Biology 8: e1000278, 2010.

Wiest MC, Thomson EE, Pantoja J, Nicolelis MAL.  Changes in S1 neural responses during tactile discrimination learning.  J. Neurophysiol. 104:300-312, 2010.

Dzirasa K, Phillips HW, Sotnikova TD, Salahpour A, Kumar S, Gainetdinov RR, Caron MG, Nicolelis MAL. Noradrenergic Control of Cortico-Striato-Thalamic and Mesolimbic Cross-Structural Synchrony. J. Neurosci. 30:6387 – 6397, 2010.

Fuentes R, Petersson P, Nicolelis MAL. Restoration of locomotive function in Parkinson’s disease by spinal cord stimulation: mechanistic approach. European J. Neurosci. 32:1100–1108, 2010.

Simões CS, Vianney P, de Moura MM, Freire MAM, Mello LE, Sameshima K, Araujo JF, Nicolelis MAL, Mello CV, Ribeiro S. Activation of frontal neocortical areas by vocal production in marmosets. Front. Integr. Neurosci. 4: 1-12, 2010.

Zhang H, Lin S-C, Nicolelis MAL.  Spatiotemporal coupling between hippocampal acetylcholine release and theta oscillations in vivo. J. Neurosci. 30: 13431-13440, 2010.

Dzirasa K, Coque L, Sidor M, Dancy EA, Takahashi J, McClung CA, Nicolelis MAL. Lithium ameliorates nucleus accumbens phase signaling dysfunction in a genetic mouse model of mania.  J. Neurosci. 30:16314-16323, 2010.

Ribeiro T, Copelli M, Chialvo D, Caixeta F, Belchior H, Nicolelis MAL, Ribeiro S. Spike

Avalanches Exhibit Universal Dynamics across the Sleep-Wake Cycle. PLoS ONE 5:e14129, 2010.


Oliveira-Maia AJ, Stapleton-Kotloski JR, Lyall V, Phan Tam-Hao T, Mummalaneni S, Melone P, DeSimone JA , Nicolelis MAL, Simon  SA. Nicotine activates TRPM5-dependent and independent taste pathways. PNAS 106: 1596-1601, 2009.

Fuentes R, Petersson P, Siesser WB, Caron MG, Nicolelis MAL. Spinal Cord Stimulation Restores Locomotion in Animal Models of Parkinson’s disease. Science 323: 1578-82, 2009.

Zhang H, Lin S-C, Nicolelis MAL. Acquiring local field potential information from amperometric neurochemical recordings. J. Neurosci Methods 179: 191-200, 2009.

Fitzsimmons N, Lebedev MA, Peikon I,  Nicolelis MAL. Extracting kinematic parameters for monkey bipedal walking from cortical neuronal ensemble activity. Front. Integr. Neurosci. 3: 1-19, 2009.

Peikon ID, Fitzsimmons NA, Lebedev MA, Nicolelis MAL. Three-dimensional, automated, real-time video system for tracking limb motion in brain-machine interface studies. J. Neurosci. Methods  180: 224-233, 2009.

Dzirasa K, Santos LM, Ribeiro S, Stapleton J, Gainetdinov RR, Caron MG, Nicolelis MAL. Persistent hyperdopaminergia decreases the peak frequency of hippocampal theta oscillations during quiet waking and REM sleep. PLoS One 4:e5238, 2009.

Zacksenhouse M, Nemets S, Lebedev MA, Beiser K, Nicolelis MAL. Robust satisficing Linear Regression: robustness/performance trade-off and consistency criterion. Mechanical-Systems and Signal Processing (MSSP) (Special Issue on Inverse Problems) 23: 1954–1964, 2009.

Rizk M, Bossetti CA, Jochum TA, Callender SH, Nicolelis MA, Turner DA, Wolf PD. A fully implantable 96-channel neural data acquisition system. J Neural Eng. Apr;6(2):026002. Epub 2009 Mar 2, 2009.

Nicolelis MAL, Lebedev MA. Principles of Neural Ensemble Physiology Underlying the Operation of Brain-Machine Interfaces. Nat. Rev. Neurosci. 10: 530-540, 2009.

Dzirasa K, Ramsey AJ, Takahashi DY, Stapleton J, Potes JM, Williams JK, Gainetdinov RR, Sameshima K, Caron MG,  Nicolelis MAL. Hyperdopaminergia and NMDA receptor hypofunction disrupt neural phase signaling. J. Neurosci. 29: 8215-8224, 2009.

Alexander GM,  Rogan SC,  Abbas AI, Armbruster BN,  Pei Y, Allen JA, Nonneman RJ, Hartmann J, Moy SS, Nicolelis MA, McNamara JO, Roth BL. Remote Control of Neuronal Activity in Transgenic Mice Expressing Evolved G Protein-Coupled Receptors. Neuron 63: 27–39, 2009.

Li Z, O’Doherty JE, Hanson TL, Lebedev MA, Henriquez CS, Nicolelis MAL. Unscented Kalman Filter for Brain-Machine Interfaces. PLoS One 4: e6243, 2009.

Petermann T, Thiagarajan TC, Lebedev MA, Nicolelis MA, Chialvo DR, Plenz D. Spontaneous cortical activity in awake monkeys composed of neuronal avalanches. Proc Natl Acad Sci. 106: 15921-15926, 2009.

O’Doherty JE, Lebedev MA, Hanson TL, Fitzsimmons NA, Nicolelis MAL. A brain-machine interface instructed by direct intracortical microstimulation. Front. Integr. Neurosci. 3: 1-10, 2009.

MacDonald CJ, Meck WH, Simon SA, Nicolelis MAL. Taste-Guided Decisions Differentially Engage Neuronal Ensembles across Gustatory Cortices. J. Neurosci. 29:11271-82, 2009.


Lebedev MA, O’Doherty JE, Nicolelis MAL. Decoding of temporal intervals from cortical ensemble activity.  J Neurophysiol 99: 166-186, 2008.

da Silva LIL, Nicolelis MAL, Haddad F. Brazil’s Option for Science Education. Sci Am 298: 25, 2008.

Nicolelis MAL. Building the Knowledge Archipelago. Sci Am 298:, 2008.

Nicolelis MAL, Chapin JK. Controlling robots with the mind.  Sci Am Reports 18: 72-79, 2008

de Araujo IE, Oliveira-Maia AJ, Sotnikova TD, Gainetdinov RR, Caron MG , Nicolelis MAL, Simon SA. Reward in the absence of taste receptor signaling. Neuron 57: 930-941, 2008.

Simon SA, de Araujo IE, Stapleton JR, Nicolelis MAL. Multisensory Processing of Gustatory Stimuli.  Chemosensory Perception 1: 95-102, 2008.

Lin S-C, Nicolelis MAL.  Neuronal ensemble bursting in the basal frontal forebrain encodes salience irrespective of valence.  Neuron 59: 138–149, 2008.


Costa RM., Gutierrez R., Kloth AD, Coelho M, de Araujo IE, Gainetdinov RR, Caron MG, Nicolelis MAL, Simon SA. Dopamine modulates the updating of tastant values. Genes, Brain & Behavior 6: 314-320, 2007.

Ribeiro S, Shi X, Engelhard M, Zhou Y, Gervasoni D, Lin S-C, Zhang H, Wada K, Nicolelis MAL. Novel experience induces persistent sleep-dependent plasticity in the cortex but not in the hippocampus. Frontiers in Neurosci 1: 43-55, 2007.

Stapleton J, Lavine ML, Nicolelis MA, Simon SA. Ensembles of gustatory cortical neurons anticipate and discriminate between tastants in a single lick. Frontiers in Neurosci 1: 161-174, 2007.

Fitzsimmons N, Drake W, Hanson T, Lebedev M, Nicolelis MAL.  Primate reaching cued by multichannel spatiotemporal cortical microstimulation.  J Neurosci  27: 5593-5602, 2007.

Soares ES, Stapleton JR, Rodriguez A, Fitzsimmons N, Oliveira L, Nicolelis MA, Simon SA.  Behavioral and neural responses to gustatory stimuli delivered non-contingently through intra-oral cannulas.  Physiol Behav 92: 629-642, 2007.

Zacksenhouse M, Lebedev MA, Carmena JM, O’Doherty JE, Henriquez C, Nicolelis MAL. Cortical modulations increase in early sessions with brain-machine interface.  PLoS ONE 2:e619, 2007.

Pantoja J, Ribeiro S, Wiest M, Soares E, Gervasoni D, Nelson L,  Nicolelis MAL. Neuronal activity in the primary somatosensory thalamocortical loop is modulated by reward contingency during tactile discrimination.  J Neurosci 27: 10608-10620, 2007.

Kim HK, Carmena JM, Biggs SJ, Hanson TL, Nicolelis MAL, Srinivasan MA.  The muscle activation method:  an approach to impedance control of brain-maching interfaces through a musculoskeletal model of the arm.  IEEE Trans Biomed Eng  54: 1520-1529, 2007.

Pereira A, Ribeiro S, Wiest M, Moore LC, Pantoja J, Lin S-C, Nicolelis MAL.Processing of tactile information by the  hippocampus. PNAS 104: 18286-18291 (Epub) November 2007.

Nicolelis MAL.  Living with Ghostly Limbs.  Sci Am Mind 18: 53-59, 2007.


Gutierrez R, Carmena J, Nicolelis, MAL, Simon SA.  Orbitofrontal ensemble activity predicts licking and distinguishes among reward.  J Neurophysiol 95:119-133, 2006.

Kim HK, Biggs J, Schloerb DW, Carmena JM, Lebedev MA, Nicolelis MAL, Srinivasan MA.  Continuous shared control stabilizes reaching and grasping with brain machine interfacesIEEE Trans Biomed Eng 53: 1164-1173, 2006.

Stapleton J, Lavine M, Wolpert R, Nicolelis MAL, Simon SA.  Rapid taste responses in the gustatory cortex during licking.  J Neurosci 26:4126-4138, 2006.

Kim SP, Sanchez JC, Rao YN, Erdogmus D, Carmena JM, Lebedev MA, Nicolelis MA, Principe JC. A comparison of optimal MIMO linear and nonlinear models for brain-machine interfaces. J Neural Eng. 3:145-161, 2006.

Lebedev MA, Nicolelis MAL. Brain machine interfaces: Past, present and future. Trends Neurosci 29: 536-546, 2006.

de Araujo IE, Gutierrez R, Oliveira-Maia AJ, Pereira Jr  A, Nicolelis MAL, Simon SA.Neural ensemble coding of satiety states.  Neuron 51:483-494, 2006.

Lin SC, Gervasoni D, Nicolelis MAL.  Fast modulation of prefrontal cortex activity by basal forebrain non-cholinergic neuronal ensembles.  J Neurophysiol 96: 3209-3219, 2006.

Dzirasa K, Ribeiro S, Costa RM, Santos LM, Lin S-C, Grosmark A, Sotnikova TD, Gainetdinov RR, Caron MG,  Nicolelis MAL. Dopaminergic control of sleep-wake states. J Neurosci 26: 10577-10589, 2006.

Costa RM, Lin S-C, Sotnikova TD, Cyr M, Gainetdinov RR, Caron MG, Nicolelis MAL. Rapid alterations in corticostriatal ensemble coordination during acute dopamine-dependent motor dysfunction. Neuron 52: 359-369, 2006.

Nicolelis MAL, Ribeiro S. Seeking the neural code.  Sci Am 295: 70-77, 2006.

Simon SA, de Araujo IE, Gutierrez R,  Nicolelis MAL. The neural mechanisms of gustation. Nature Rev Neurosci 7: 890-901, 2006.


Costa RM, Liu L, Nicolelis MAL, Simon SA. Gustatory effects of capsaicin that are independent of TRPV1 receptors.  Chem Senses 30: i198-i200, 2005.

Lebedev MA, Carmena JM, O’Doherty JE, Zacksenhouse M, Henriquez CS, Principe J, Nicolelis MAL.  Cortical ensemble adaptation to represent velocity of an artificial actuator controlled by a brain machine interface. J Neurosci 25: 4681-4693, 2005.

Wiest MC, Bentley N, Nicolelis MAL.  Heterogeneous integration of bilateral whisker signals by neurons in primary somatosensory cortex of awake rats.  J Neurophysiol 93: 2966-2973, 2005.

Nicolelis, MAL. Computing with thalamocortical ensembles during different behavioral states. J Physiol 566.1: 37-47, 2005.

Santucci DM, Kralik JD, Lebedev MA, Nicolelis MAL.  Frontal and parietal cortical ensembles predict muscle activity during reaching movements in primates. European J Neurosci 22:  1529-1540, 2005.

Carmena JM, Lebedev MA, Henriquez CS, Nicolelis MAL.  Stable ensemble performance with single neuron variability during reaching movements in primates. J Neurosci 25: 10712-10716, 2005.

Sanchez JC, Erdogmus D, Principe JC, Wessberg J, and Nicolelis MAL. Interpreting spatial and temporal neural activity through a recurrent neural network brain machine interface. IEEE Trans Neural Syst Rehabil Eng 15: 213-219, 2005.


Ribeiro S, Gervasoni D, Soares E, Zhou Y, Lin S-C, Pantoja J, Lavine M, Nicolelis MAL. Long-lasting novelty-induced neuronal reverberation during slow-wave sleep in multiple forebrain areas. Public Library of Science 2: 126-137, 2004.

Obeid I., Nicolelis MAL, Wolf P. A low power multichannel analog front end for portable neural signal recordings. J Neurosci Meth 133: 27-32, 2004

Obeid I., Nicolelis MAL, Wolf P. A multichannel telemetry system for single unit neural recordings. J Neurosci Meth 133: 33-38, 2004.

Cohen D, Nicolelis MAL. Reduction of single neuron firing uncertainty by cortical ensembles during motor skill learning. J Neurosci 24: 3574-3582, 2004.

Patil PG, Carmena JM, Nicolelis MAL, Turner DA.  Ensemble recordings of human subcortical neurons as a source of motor control signals for a brain-machine interface. J Neurosurgery 55: 27-35, 2004.

Krupa DJ, Wiest, MC, Laubach M, Nicolelis MAL Layer specific somatosensory cortical activation during active tactile discrimination   Science 304: 1989-1992, 2004.

Costa RM, Cohen D, Nicolelis MAL. Differential cortico-striatal plasticity during fast and slow motor skill learning in mice. Curr Biol 14: 1124-1134, 2004.

Wessberg J, Nicolelis MAL. Optimizing a linear algorithm for real-time robotic control using chronic cortical ensemble recordings in monkeys. J Cogn Neurosci 16: 1022-1035, 2004.

Bossetti CA, Carmena JM, Nicolelis MAL, Wolf PD.  Transmission latencies in a telemetry-linked brain-machine interface.  IEEE Trans Biomed Egr 51: 919-924, 2004.

Sanchez JC, Carmena JM, Lebedev MA, Nicolelis MAL, Harris JG, Principe JC.  Ascertaining the importance of neurons to develop better brain-machine interfaces.  IEEE Trans Biomed Egr 51: 943-953, 2004.

Gervasoni D, Shih-Chieh L, Ribeiro S, Soares ES, Pantoja J, Nicolelis MA.L. Global forebrain dynamics predict rat behavioral states and their transitions. J Neurosci 24: 11137-11147, 2004.

Ribeiro S, Nicolelis MAL.  Reverberation, storage and post-synaptic propagation of memories during sleep.  Learn Mem 11: 686 – 696, 2004.


Obeid I, Morizio JC, Moxon KA, Nicolelis MAL, Wolf PD. Two multichannel integrated circuits for neural recording and signal processing. IEEE Trans Biomed Egr 50: 255-258, 2003.

Nicolelis MAL. Brain-machine interfaces to restore motor function and probe neural circuits. Nat Rev Neurosci 4: 417-422, 2003.

Matell MS, Meck WH, Nicolelis MAL. Interval timing and the encoding of signal duration by ensembles of cortical and striatal neurons. Behavioral Neurosci 117: 760-773, 2003.

Nicolelis MAL, Dimitrov DF, Carmena J, Crist R, Lehew G, Kralik J, Wise S. Chronic, multi-site, multi-electrode recordings in macaque monkeys. PNAS 100: 11041-11046, 2003.

Wiest M, Nicolelis MAL. Behavioral detection of tactile stimuli during 7-12 Hz cortical oscillations in awake rats. Nat Neurosci 6: 913-914, 2003.

Carmena JM, Lebedev MA, Crist RE, O’Doherty JE, Santucci DM, Dimitrov DR, Patil PG, Henriquez CS, Nicolelis MAL.  Learning to control a brain-machine interface for reaching and grasping by primates. Public Library of Science 1: 193-208, 2003.


Shuler M, Krupa DJ, Nicolelis MAL. Integration of bilateral whisker stimuli in rats: role of the whisker barrel cortices.  Cerebral Cortex 12: 86-97, 2002.

Katz D, Simon SA, Nicolelis MAL. Taste-specific neuronal ensembles in the gustatory cortex of awake rats. J Neurosci 22: 1850-1857, 2002.

Nicolelis MAL, Fanselow E. Thalamocortical optimization of tactile processing according to behavioral state. Nature Neurosci 5: 517-523, 2002.

Nicolelis MAL. Depression at thalamocortical synapses: the key for cortical neuronal adaptation? Neuron 34: 331-2, 2002.

Nicolelis MAL, Chapin JK. Controlling robots with the mind. Scientific American 287: 24-31, October 2002.

Katz D, Nicolelis MAL, Simon SA. Gustatory processing is dynamic and distributed. Curr Opinion Neurobiol 12: 448-454, 2002.

Nicolelis MAL. The amazing adventures of robotrat. Trends Cogn Neurosci 6: 449-450, 2002.

Nicolelis MAL, Ribeiro S. Multi-electrode recordings: the next steps. Curr Opinion Neurobiol 12: 602-606, 2002.

Nicolelis MAL, Fanselow E. Dynamic shifting in thalamocortical processing during different behavioral states. Phil Trans R Soc Lond B 357: 1753-1758, 2002.


Das A, Franca JG, Gattass R, Kaas JH, Nicolelis MA, Timo-Iaria C, Vargas CD, Weinberger NM, Volchan E. The brain decade in debate: VI. Sensory and motor maps: dynamics and plasticity.  Braz J Med Biol Res   34: 1497-508, 2001.

Nicolelis MAL. Actions from thoughts. Nature 409: 403-407, 2001.

Krupa DJ, Brisben AJ, Nicolelis MAL. A multi-channel whisker stimulator for producing spatiotemporally complex tactile stimuli. J Neurosci Meth 104: 199-208, 2001.

Ghazanfar AA, Nicolelis MAL. The structure and function of dynamic cortical and thalamic receptive fields. Cerebral Cortex 11: 183-193, 2001.

Katz D, Simon S, Nicolelis MAL. Dynamic and multimodal responses of gustatory cortical neurons in awake rats.  J Neurosci 21: 4478-4489, 2001.

Nicolelis MAL, Shuler M. Thalamocortical and corticocortical interactions in the somatosensory system.  Prog Brain Res 130: 89-110, 2001.

Shuler M, Krupa DJ, Nicolelis MAL. Bilateral integration of whisker information in the primary somatosensory cortex of rats.  J Neurosci 21: 5251-5261, 2001.

Krupa DJ, Matell MS, Brisben AJ, Oliveira LM, Nicolelis MAL. Behavioral properties of the trigeminal somatosensory system in rats performing whisker-dependent tactile discriminations.  J Neurosci 21: 5752-5763, 2001.

Ghazanfar AA, Krupa DJ, Nicolelis MAL. Role of cortical feedback in the receptive field structure and nonlinear response properties of somatosensory thalamic neurons. Exp Brain Res 141: 88-100, 2001.

Fanselow EE, Sameshima K, Baccala LA, Nicolelis MAL. Thalamic bursting in rats during different awake behavioral states. PNAS 98: 15330-15335, 2001.

Kralik JD, Dimitrov DF, Krupa DJ, Katz DB, Cohen D, Nicolelis MAL. Techniques for long-term multisite neuronal ensemble recordings in behaving animals.   Methods 25: 121-150, 2001.


Katz D, Nicolelis MAL, Simon S. There is more to taste than meets the tongue. Am J Physiol 278: G6-G9, 2000.

Ghazanfar AA, Stambaugh CR, Nicolelis MAL. Encoding of tactile stimulus location by somatosensory thalamocortical ensembles. J Neurosci 20: 3761-3775, 2000.

Fanselow EE, Reid AP, Nicolelis MAL. Reduction of pentylenetetrazole-induced seizure activity in awake rats by seizure-triggered trigeminal nerve stimulation. J Neurosci 20:  8160-8168, 2000.

Krupa DJ, Nicolelis MAL. Network level properties of short-term plasticity in the somatosensory system. Progress Brain Res 128: 161-172, 2000.

Laubach M, Wessberg J, Nicolelis MAL. Cortical ensemble activity increasingly predicts behavior outcomes during learning of a motor task. Nature 405: 567-571, 2000.

Wessberg J, Stambaugh CR, Kralik JD, Beck PD, Chapin JK, Kim J, Biggs SJ, Srinivasan MA, Nicolelis MAL. Real-time prediction of hand trajectory by ensembles of cortical neurons in primates. Nature 408: 361-365, 2000.


Krupa DJ, Ghazanfar AA, Nicolelis MAL. Immediate thalamic sensory plasticity depends on corticothalamic feedback. PNAS 96: 8200-8205, 1999.

Ghazanfar AA, Nicolelis MAL. Spatiotemporal properties of layer V neurons in the rat primary somatosensory cortex. Cerebral Cortex 9: 348-361, 1999.

Katz, DB, Simon SA, Nicolelis MAL. Simultaneous reorganization in thalamocortical ensembles evolves over several hours after perioral capsaicin injections. J Neurophysiol 82: 963-977, 1999.

Fanselow E, Nicolelis MAL. Behavioral modulation of tactile responses in the rat somatosensory system. J Neurosci 19: 7603-7616, 1999.

Chapin JK, Nicolelis MAL. Principal component analysis of neuronal ensemble activity reveals multidimensional somatosensory representations.  J Neurosci Meth 94: 121-140, 1999.

Laubach M, Shuler M, Nicolelis MAL. Independent component analyses for quantifying neuronal ensemble interactions. J Neurosci Meth 94: 141-154, 1999.

Chapin JK, Moxon KA, Markowitz RS, Nicolelis MAL. Real-time control of a robot arm using simultaneously recorded neurons in the motor cortex. Nature Neurosci 2: 664-670, 1999.


Nicolelis MAL, Krupa DJ, Katz D. Potential circuit mechanisms underlying concurrent thalamic and cortical plasticity. Rev Neurosci 9: 213-224, 1998.

Nicolelis MAL, Ghazanfar AA, Stambaugh CH, Oliveira LMO, Laubach M, Chapin JK, Nelson R, Kaas JH. Simultaneous encoding of tactile information by three primate cortical areas. Nature Neurosci 1: 621-630, 1998.


Lin CS, Nicolelis MAL, Chapin JK. Topography and laminar organization of the incertocortical pathway in rats. Neuroscience 81: 641-651, 1997.

Nicolelis MAL, Lin RCS, Chapin JK. Neonatal whisker deprivation alters the encoding of tactile information by ensembles of thalamic neurons. J Neurophysiol 78: 1691-1706, 1997.

Ghazanfar AA, Nicolelis MAL. Nonlinear processing of tactile information in the thalamocortical loop. J Neurophysiol 78: 506-510, 1997.

Nicolelis MAL, Ghazanfar AA, Faggin B, Votaw S, Oliveira LMO. Reconstructing the engram: simultaneous, multisite, many single neuron recordings. Neuron 18: 529-537, 1997.

Nicolelis MAL. Dynamic and distributed somatosensory representations as the substrate for cortical and subcortical plasticity. Seminars in Neurosciences 9: 24-33, 1997.

Faggin BM, Ngyuen KT, Nicolelis MAL. Immediate and simultaneous sensory reorganization at cortical and subcortical levels of the somatosensory system. PNAS 94: 9428-9433, 1997.

Nicolelis MAL, Fanselow E, Ghazanfar AA. Hebb’s dream:  the resurgence of cell assemblies. Neuron 19: 219-221, 1997.


Chapin JK, Nicolelis MAL. Neural network mechanisms of oscillatory brain states: characterization using simultaneous multi-single neuron recordings. In: Continuous waveform analysis, R.M. Basheiss and D.J. Vicent (eds). Electroenceph Clin Neurophysiol, suppl 45, pp 113-122, 1996.

Nicolelis MAL, Oliveira LMO, Lin RCS, Chapin JK. Active tactile exploration influences the functional maturation of the somatosensory system. J. Neurophysiol 17: 2192-2196, 1996.

Nicolelis MAL. Beyond maps: A dynamic view of the somatosensory system. Braz J Med Biol Res 29: 401-412, 1996.

Lin RCS, Nicolelis MAL, Zhou HL, Chapin JK. Calbindin-containing, non-specific thalamocortical projecting neurons in the rat. Brain Res 711: 50-55, 1996.


Nicolelis MAL, Chapin JK, Lin RCS. Development of the direct projections from the zona incerta to the primary somatosensory cortex in rats. Neuroscience 65: 609-631, 1995.

Nicolelis MAL, Baccala LA, Lin RCS, Chapin JK. Sensorimotor encoding by synchronous neural ensemble activity at multiple levels of the somatosensory system. Science 268: 1353-1358, 1995.


Nicolelis MAL, Chapin JK. The spatiotemporal structure of somatosensory responses of many-neuron ensembles in the rat ventral posterior medial nucleus of the thalamus. J Neurosci 14: 3511-3532, 1994.


Nicolelis MAL, Lin RCS, Woodward DJ, Chapin JK. Dynamic and distributed properties of many-neuron ensembles in the ventral posterior medial (VPM) thalamus of awake rats. PNAS 90: 2212-2216, 1993.

Nicolelis MAL, Lin RCS, Woodward DJ, Chapin JK. Induction of immediate spatiotemporal changes in thalamic networks by peripheral block of ascending cutaneous information. Nature 361: 533-536, 1993.


Nicolelis MAL, Chapin JK, Lin RCS. Somatotopic maps within the zona incerta relay parallel GABAergic somatosensory pathways to the neocortex, superior colliculus, and brainstem. Brain Res 577: 134-141, 1992.


Nicolelis MAL, Lin CS, Chapin, JK. Ontogeny of corticortical projections of the rat somatosensory cortex. Somat Mot Res 8: 193-200, 1991.

Nicolelis MAL, Chapin JK, Lin RCS. Thalamic plasticity induced by early whisker removal in rats. Brain Res 561: 344-349, 1991.

Nicolelis MAL, Chapin JK, Lin RCS. Neonatal whisker removal in rats stabilizes a transient projection from the auditory thalamus to the primary somatosensory cortex. Brain Res 567: 133-139, 1991.

Nicolelis MAL, Baccala LA. Rhythms in the bacterial sensitivity behavior at a large hospital. J Clin Epidemiol 44(2): 191-205, 1991.

Baccala LA, Nicolelis MAL, Yu CH. Structural analysis of neural circuits using the theory of directed graphs. Comput Biomed Res 24: 7-28, 1991.


Lin CS, Nicolelis MAL, Schneider JS, Chapin JK. A major direct GABAergic pathway from zona incerta to neocortex. Science 248: 1553-1556, 1990.

Nicolelis MAL, Yu CH, Baccala LA. Structural characterization of the neural circuit responsible for the cardiovascular function control in high vertebrates. Comput Biol Med 20(6): 379-400, 1990.


Montes GS, Nicolelis MAL, Brentani-Samaia HP, Furuie SS. Collagen fibril diameters in mice arteries: A comparison of manual and computer-aided morphometric analyses. Acta Anatomica 135: 57-61, 1989.

Nicolelis MAL, Tinone G, Sameshima K, Timo-Yaria C, Yu CH, Van de Bild MT. Connection, a microcomputer program for storing and analyzing neural circuits. Comput Biomed Res 23: 64-81, 1989.

Yu CH, Baccala LA, Nicolelis MAL. Applying graph theory on a neural network responsible for the cardiovascular function control: a correlation between structural properties and physiological functions. In: Proceedings of the VI Conference on Medical Informatics. (B. Barber, D. Cao, D. Qin and G. Wagner, eds) pp 87-91, Singapore, 1989.

Baccala LA, Nicolelis MAL. Using computers to survey the epidemiological, environmental and genetic factors involved in the process of bacterial resistance acquisition. XIII Symposium on Computer Application in Medical Care, pp 261-265, 1989.


Nicolelis MAL, Baccala LA. Time series analysis of rhythmic bacterial resistance development to antibiotics. Comput Biomed Res 21: 137-157, 1988.

Lages S, Gutierrez MA, Nicolelis MAL, Furuie SS. A bedside computerized system for monitoring and processing biological signals in an intensive care unit. Proceedings of the XIV Computers in Cardiology Congress, IEEE Computer Society, Leuven, 561-564, 1988.

Gutierrez MA, Furuie SS, Nicolelis MAL, Lages S. Developing a multi-purpose microcomputer-based system for biological signal analysis to cardiovascular protocols. Proceedings of the XIV Computers in Cardiology Congress, IEEE Computer Society, 505-508, 1988.

Nicolelis MAL, Yu CH. Application of a microcomputer-based system in the analysis of infection data at the emergency units of a large hospital. Int J Biomed Comput 22: 183-198, 1988.

Nicolelis MAL, Baccala LA. Do bacteria have an intrinsic rhythmic sensitivity pattern? Critical Care Med 16(6): 650, 1988.

Bohm GM, Massad E, Nicolelis MAL, Sameshima K. Teaching medical informatics at the Faculty of Medicine, University of Såo Paulo, Brazil. In: Lecture notes in medical informatics, Proceedings of the VIII International Congress on Medical Informatics Europe 88, P.L. Reichertz and D.A.B. Lindberg eds, Springer-Verlag, 35: 316-320, 1988.

Nicolelis MAL, Yu CH. Defining criteria for quantitative analysis of the neural network responsible for the cardiovascular function control by means of a microcomputer system. In. Proceedings of the XII Symposium on Computer Applications in Medical Care, R.A. Greenes ed., IEEE Computer Society, Washington, 256-260, 1988.

Nicolelis MAL, Younes RN. Dissociation of left and right ventricle heart beats during severe hemorrhagic shock in dogs. Circ Shock 28(4): 281-282, 1988.

Nicolelis MAL. Development of an integrated microcomputer-based system and its application in the analysis of neural network structural properties and biological signal processing. Ph.D. thesis, Institute of Biomedical Science, University of Sao Paulo, 1988.


Nicolelis MAL, Massad E, Utzler R, Engel A, Rodrigues E, Bazzone JRC, Tomida RM. Mathematical model of Klebsiella pneumoniae’s resistance to amikacin and gentamicin. Braz J Med Biol Res 20: 35-41, 1987.

Massad E, Engel A, Nicolelis MAL. A mathematical model for spirometry. Comput Biomed Res 20(2): 105-112, 1987.

Nicolelis MAL, Sameshima K, Furuie SS, Gutierrez MA. A signal processing system to analyze the neural control on the cardiovascular function. Proceedings of the VII International Congress Medical Informatics Europe, Rome, 1987, Vol 3, 1318-1322.


Nicolelis MAL, Martins MA, Meireles LP, Birolini D. Computer-aided analysis of patterns of bacterial incidence and sensitivity in a surgical unit. Rev Assoc Med Brasil 32: 134-140, 1986 (Portuguese).

Nicolelis MAL, Baccala LA, Tinone G, Yu CH. Mathematical approach to bacterial sensitivity rhythm patterns. Proceedings of the MEDINFO Congress, Ifip-Imia, Washington, 480-482, 1986.


Saldiva PHN, Massad E, Caldeira MPR, Calheiros DF, Saldiva CD, Nicolelis MAL, Bohm GM. Pulmonary function of rats exposed to ethanol and gasoline fumes. Brazilian J Med Biol Res 18: 573-577, 1985.

Massad E, Furuie SS, Moura Jr LA, Saldiva PHN, Nicolelis MAL, Bohm GM. The use of a personal computer in the pulmonary function tests of laboratory rats. Meth Inform Med 24: 197-199, 1985.

Nicolelis MAL, Carvalho CRR. Computer-aided standardization of antimicrobial therapeutics. Rev Hosp Clin Fac Med Sao Paulo 40: 227-232, 1985 (Portuguese).


Fillho JW, Schoveri Jr. R, Garcia YM, Machado C, Ferreira ML, Barreira PL, Batista MC, Nicolelis MAL, Carvalho Filho ET. Comparative analysis of methods for evaluation of the renal function in elders. Geriatria em Sintese 1: 14-16, 1984 (Portuguese)