{"id":345,"date":"2013-02-12T16:25:25","date_gmt":"2013-02-12T16:25:25","guid":{"rendered":"http:\/\/www.nicolelislab.net\/?p=345"},"modified":"2013-02-14T22:19:36","modified_gmt":"2013-02-14T22:19:36","slug":"neuroprosthesis-gives-rats-the-ability-to-touch-infrared-light","status":"publish","type":"post","link":"http:\/\/www.nicolelislab.net\/?p=345","title":{"rendered":"Neuroprosthesis Gives Rats the Ability to \u201cTouch\u201d Infrared Light"},"content":{"rendered":"<p><a href=\"http:\/\/www.nicolelislab.net\/wp-content\/uploads\/2013\/02\/Screen-Shot-2013-02-11-at-5.18.51-PM.png\"><img loading=\"lazy\" decoding=\"async\" class=\"alignright size-medium wp-image-346\" title=\"Screen Shot 2013-02-11 at 5.18.51 PM\" src=\"http:\/\/www.nicolelislab.net\/wp-content\/uploads\/2013\/02\/Screen-Shot-2013-02-11-at-5.18.51-PM-300x215.png\" alt=\"\" width=\"300\" height=\"215\" srcset=\"http:\/\/www.nicolelislab.net\/wp-content\/uploads\/2013\/02\/Screen-Shot-2013-02-11-at-5.18.51-PM-300x215.png 300w, http:\/\/www.nicolelislab.net\/wp-content\/uploads\/2013\/02\/Screen-Shot-2013-02-11-at-5.18.51-PM-230x165.png 230w, http:\/\/www.nicolelislab.net\/wp-content\/uploads\/2013\/02\/Screen-Shot-2013-02-11-at-5.18.51-PM-200x143.png 200w, http:\/\/www.nicolelislab.net\/wp-content\/uploads\/2013\/02\/Screen-Shot-2013-02-11-at-5.18.51-PM-130x93.png 130w, http:\/\/www.nicolelislab.net\/wp-content\/uploads\/2013\/02\/Screen-Shot-2013-02-11-at-5.18.51-PM.png 668w\" sizes=\"auto, (max-width: 300px) 100vw, 300px\" \/><\/a>Sensory neuroprostheses show great potential for alleviating major sensory de\ufb01cits. It is not known, however, whether such devices can augment the subject\u2019s normal perceptual range. Here we show that adult rats can learn to perceive otherwise invisible infrared light through a neuroprosthesis that couples the output of a head-mounted infrared sensor to their somatosensory cortex (S1) via intracortical microstimulation. Rats readily learn to use this new information source, and generate active exploratory strategies to discriminate among infrared sources in their environment. S1 neurons in these infrared-perceiving rats respond to both whisker de\ufb02ection and intracortical microstimulation, suggesting that the infrared representation does not displace the original tactile representation. Hence, sensory cortical prostheses, in addition to restoring normal neurological functions, may serve to expand natural perceptual capabilities in mammals. <a href=\"http:\/\/www.nicolelislab.net\/wp-content\/uploads\/2013\/02\/Neuroprosthesis-Gives-Rats-the-Ability-to-Touch-Infrared-Light1.pdf\" target=\"_blank\">Read Full Article Here<\/a><\/p>\n<hr \/>\n<h4>VIDEOS<\/h4>\n<p><iframe loading=\"lazy\" src=\"http:\/\/www.youtube.com\/embed\/GZ2Y81ATVEk?rel=0\" frameborder=\"0\" width=\"560\" height=\"315\"><\/iframe><br \/>\n<strong><strong>Infrared\u00a0<\/strong>Movie S1:<\/strong> Introduction to the structure of the task. Two views of a rat performing a single trial of the IR-discrimination task. The IR light comes on, and when the rat orients toward the stimulus, an IR-signal is registered by an IR-detector on the rat\u2019s head, and S1 is stimulated with a frequency that depends on detector\u2019s output (Figure 1e). Guided by microstimulation, the rat approaches the reward port to receive water. In the floor-level view, you can see the infrared detector attached to the rat&#8217;s head. The audio track is the output of the microstimulator, which is not available to the rat.<\/p>\n<p><iframe loading=\"lazy\" src=\"http:\/\/www.youtube.com\/embed\/nsniwzap2qE?rel=0\" frameborder=\"0\" width=\"560\" height=\"315\"><\/iframe><br \/>\n<strong>Infrared Movie S2:<\/strong>\u00a0 Example of rat performing IR discrimination (top-down view). Movie shows three trials in a well-trained rat navigating the chamber actively foraging for IR sources. The ports are 90 degrees apart.<\/p>\n<p><iframe loading=\"lazy\" src=\"http:\/\/www.youtube.com\/embed\/_tcGCPQ7O9Y?rel=0\" frameborder=\"0\" width=\"560\" height=\"315\"><\/iframe><br \/>\n<strong>Infrared Movie S3:\u00a0<\/strong> Example of IR-discrimination in difficult version of task. Multiple trials in a well-trained animal on a more difficult version of the task than shown in Movie 2:\u00a0 the reward ports are only 30\u00b0 apart. Correct and incorrect trials are indicated.<\/p>\n<p><iframe loading=\"lazy\" src=\"http:\/\/www.youtube.com\/embed\/3EIT5Jf1p7w?rel=0\" frameborder=\"0\" width=\"560\" height=\"420\"><\/iframe><br \/>\n<strong>Infrared Movie S4:<\/strong> Sample trials from a session with \u2018blank\u2019 trials interleaved. On random trials the IR light is activated, but is uncoupled from ICMS. Trial types (\u2018stim\u2019 versus \u2018no-stim\u2019 trials) are indicated before each trial.<\/p>\n<hr \/>\n<h4>Download PDF of the Press Release<\/h4>\n<p><a href=\"http:\/\/www.nicolelislab.net\/wp-content\/uploads\/2013\/02\/DCNE-02122013.pdf\" target=\"_blank\">Neuroprosthesis Gives Rats the Ability to &#8220;Touch&#8221; Infrared Light (PDF)<\/a><\/p>\n<hr \/>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Sensory neuroprostheses show great potential for alleviating major sensory de\ufb01cits. It is not known, however, whether such devices can augment the subject\u2019s normal perceptual range. Here we show that adult rats can learn to perceive otherwise invisible infrared light through &hellip; <a href=\"http:\/\/www.nicolelislab.net\/?p=345\">Continue reading <span class=\"meta-nav\">&rarr;<\/span><\/a><\/p>\n","protected":false},"author":1,"featured_media":346,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[4],"tags":[],"class_list":["post-345","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-recent-findings"],"_links":{"self":[{"href":"http:\/\/www.nicolelislab.net\/index.php?rest_route=\/wp\/v2\/posts\/345","targetHints":{"allow":["GET"]}}],"collection":[{"href":"http:\/\/www.nicolelislab.net\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"http:\/\/www.nicolelislab.net\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"http:\/\/www.nicolelislab.net\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"http:\/\/www.nicolelislab.net\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=345"}],"version-history":[{"count":15,"href":"http:\/\/www.nicolelislab.net\/index.php?rest_route=\/wp\/v2\/posts\/345\/revisions"}],"predecessor-version":[{"id":367,"href":"http:\/\/www.nicolelislab.net\/index.php?rest_route=\/wp\/v2\/posts\/345\/revisions\/367"}],"wp:featuredmedia":[{"embeddable":true,"href":"http:\/\/www.nicolelislab.net\/index.php?rest_route=\/wp\/v2\/media\/346"}],"wp:attachment":[{"href":"http:\/\/www.nicolelislab.net\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=345"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"http:\/\/www.nicolelislab.net\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=345"},{"taxonomy":"post_tag","embeddable":true,"href":"http:\/\/www.nicolelislab.net\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=345"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}