{"id":293,"date":"2012-12-14T16:14:31","date_gmt":"2012-12-14T16:14:31","guid":{"rendered":"http:\/\/www.nicolelislab.net\/?p=293"},"modified":"2012-12-14T18:07:50","modified_gmt":"2012-12-14T18:07:50","slug":"large-recording-of-brain-cells-at-work-will-help-recreate-motor-function","status":"publish","type":"post","link":"http:\/\/www.nicolelislab.net\/?p=293","title":{"rendered":"Nearly Two Thousand Brain Cells Recorded at One Time"},"content":{"rendered":"
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Large-scale brain recordings. (Top) Four multielectrode arrays with 448 electrodes were inserted in rhesus monkey motor (M1) and sensory (S1) cortices of both hemispheres. (Bottom-left) Waveforms of recorded neurons from each of the 1874 cortical neurons from one monkey. Waveforms are colored separately to indicate electrode location – top to bottom: Left M1, left S1, right M1, right S1. (Bottom-right) Raster plot showing activity of all recorded neurons vs. time during a single 10 second window.<\/p><\/div>\n

DURHAM, N.C. \u2013 A milestone in a neuroscience experiment was announced this week by researchers at the laboratory of Miguel Nicolelis, M.D., PhD, at the Duke University Center for Neuroengineering, with the recording of close to 2,000 brain cells at work in a primate.<\/p>\n

By documenting the firing patterns of 1,874 neurons, the Duke team recorded its largest sample of brain electrical activity produced by populations of interconnected single neurons.<\/p>\n

The finding advances the quest of the Nicolelis\u2019 lab and its partners, which form the worldwide scientific consortium named the Walk Again Project\u2122, to build a whole-body exoskeleton that could enable paralyzed people to regain motor and sensory abilities using brain activity to control the apparatus. The Walk Again Project\u2122 aims to unveil the first version of this exoskeleton in the opening ceremony of the FIFA Soccer World Cup in June 2014.<\/p>\n

\u201cThe accuracy of neuroprosthetic devices to help paralyzed people clearly improves with the number of simultaneously recorded brain neurons, so to get high performance from these devices for multiple degrees of freedom in movement, we need to record from thousands of neurons,\u201d said Nicolelis, a professor of neurobiology at Duke Medicine.<\/p>\n

\u201cThis is the first time that we have recorded more than a thousand neurons from volumes of cortical tissue,\u201d Nicolelis said. \u201cThe cutting edge technology used to obtain these recordings, including our newly designed high-density wireless interface, opens a wide range of new opportunities for our neuroprosthetic work.\u201d<\/p>\n

Since publishing their pioneering studies on brain-machine interfaces in the late 1990s, Nicolelis and his colleagues have worked to record larger samples of cortical cells simultaneously to produce more naturally functioning neuroprosthetic devices.<\/p>\n

\u201cIt is exciting for us to be able to sample from close to two thousand single neurons in just one recording session,\u201d commented Mikhail Lebedev, senior research scientist in the Nicolelis laboratory. \u201cIn the not so distant past researchers were able to record from just one to two neurons at a time, and it would take them several years to collect the amount of neural data we are now recording in a single afternoon.\u201d<\/p>\n

The next step is to incorporate the brain-machine interface technology into a specially engineered exoskeleton created by researchers led by Dr. Gordon Cheng at the Munich Technical University.<\/p>\n

The Nicolelis group members who worked on this project included Mikhail Lebedev, Dragan Dimitrov, Gary Lehew, Peter Ifft, James Meloy, David Schwarz, Katie Zhuang, Zheng Li, Arjun Ramakrishnan, Shankari Sankaranarayani, Andrew Tate, Tamara Phillips and Laura Oliveira.<\/p>\n

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Download PDF of the Press Release<\/h4>\n

Nearly Two Thousand Brain Cells Recorded at One Time (PDF)<\/a><\/p>\n

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DURHAM, N.C. \u2013 A milestone in a neuroscience experiment was announced this week by researchers at the laboratory of Miguel Nicolelis, M.D., PhD, at the Duke University Center for Neuroengineering, with the recording of close to 2,000 brain cells at … Continue reading →<\/span><\/a><\/p>\n","protected":false},"author":1,"featured_media":294,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[4],"tags":[],"class_list":["post-293","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-recent-findings"],"_links":{"self":[{"href":"http:\/\/www.nicolelislab.net\/index.php?rest_route=\/wp\/v2\/posts\/293","targetHints":{"allow":["GET"]}}],"collection":[{"href":"http:\/\/www.nicolelislab.net\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"http:\/\/www.nicolelislab.net\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"http:\/\/www.nicolelislab.net\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"http:\/\/www.nicolelislab.net\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=293"}],"version-history":[{"count":14,"href":"http:\/\/www.nicolelislab.net\/index.php?rest_route=\/wp\/v2\/posts\/293\/revisions"}],"predecessor-version":[{"id":327,"href":"http:\/\/www.nicolelislab.net\/index.php?rest_route=\/wp\/v2\/posts\/293\/revisions\/327"}],"wp:featuredmedia":[{"embeddable":true,"href":"http:\/\/www.nicolelislab.net\/index.php?rest_route=\/wp\/v2\/media\/294"}],"wp:attachment":[{"href":"http:\/\/www.nicolelislab.net\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=293"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"http:\/\/www.nicolelislab.net\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=293"},{"taxonomy":"post_tag","embeddable":true,"href":"http:\/\/www.nicolelislab.net\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=293"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}